Selective modulation of the functions of a conserved DNA motor by a histone fold complex
作者： Dorina Saro , Hengyao Niu , Grzegorz Ira , Dana Branzei , Patrick Sung
关键词:
摘要: Budding yeast Mph1 helicase and its orthologs drive multiple DNA transactions. Elucidating the mechanisms that regulate these motor proteins is central to understanding genome maintenance processes. Here, we show conserved histone fold MHF complex promotes Mph1-mediated repair of damaged replication forks but does not influence outcome double-strand break repair. Mechanistically, scMHF relieves inhibition imposed by structural chromosome protein Smc5 on activities relevant replication-associated through binding DNA. Thus, a function-specific enhancer enables flexible response different situations.
sci-hub.se 参考文章(33)
R. Sugahara, H. Mon, J. M. Lee, T. Kusakabe, Middle region of FancM interacts with Mhf and Rmi1 in silkworms, a species lacking the Fanconi anaemia (FA) core complex Insect Molecular Biology. ,vol. 23, pp. 185- 198 ,(2014) , 10.1111/IMB.12072
Thiyam Ramsing Singh, Dorina Saro, Abdullah Mahmood Ali, Xiao-Feng Zheng, Chang-hu Du, Michael W. Killen, Aristidis Sachpatzidis, Kebola Wahengbam, Andrew J. Pierce, Yong Xiong, Patrick Sung, Amom Ruhikanta Meetei, MHF1-MHF2, a Histone-Fold-Containing Protein Complex, Participates in the Fanconi Anemia Pathway via FANCM Molecular Cell. ,vol. 37, pp. 879- 886 ,(2010) , 10.1016/J.MOLCEL.2010.01.036
Alejandro Chavez, Vishesh Agrawal, F. Brad Johnson, Homologous Recombination-dependent Rescue of Deficiency in the Structural Maintenance of Chromosomes (Smc) 5/6 Complex Journal of Biological Chemistry. ,vol. 286, pp. 5119- 5125 ,(2011) , 10.1074/JBC.M110.201608
Hui Yang, Tianlong Zhang, Ye Tao, Lijing Wu, Hong-tao Li, Jin-qiu Zhou, Chen Zhong, Jianping Ding, Saccharomyces Cerevisiae MHF Complex Structurally Resembles the Histones (H3-H4)2 Heterotetramer and Functions as a Heterotetramer Structure. ,vol. 20, pp. 364- 370 ,(2012) , 10.1016/J.STR.2011.12.012
Ingrid Lilienthal, Takaharu Kanno, Camilla Sjögren, Inhibition of the Smc5/6 Complex during Meiosis Perturbs Joint Molecule Formation and Resolution without Significantly Changing Crossover or Non-crossover Levels PLoS Genetics. ,vol. 9, pp. e1003898- ,(2013) , 10.1371/JOURNAL.PGEN.1003898
W. Crismani, C. Girard, N. Froger, M. Pradillo, J. L. Santos, L. Chelysheva, G. P. Copenhaver, C. Horlow, R. Mercier, FANCM Limits Meiotic Crossovers Science. ,vol. 336, pp. 1588- 1590 ,(2012) , 10.1126/SCIENCE.1220381
David Fox, Zhijiang Yan, Chen Ling, Ye Zhao, Duck-Yeon Lee, Tatsuo Fukagawa, Wei Yang, Weidong Wang, The histone-fold complex MHF is remodeled by FANCM to recognize branched DNA and protect genome stability. Cell Research. ,vol. 24, pp. 560- 575 ,(2014) , 10.1038/CR.2014.42
R. Prakash, D. Satory, E. Dray, A. Papusha, J. Scheller, W. Kramer, L. Krejci, H. Klein, J. E. Haber, P. Sung, G. Ira, Yeast Mph1 helicase dissociates Rad51-made D-loops: implications for crossover control in mitotic recombination Genes & Development. ,vol. 23, pp. 67- 79 ,(2009) , 10.1101/GAD.1737809
Danielle L. Daee, Elisa Ferrari, Simonne Longerich, Xiao-feng Zheng, Xiaoyu Xue, Dana Branzei, Patrick Sung, Kyungjae Myung, Rad5-dependent DNA Repair Functions of theSaccharomyces cerevisiaeFANCM Protein Homolog Mph1 Journal of Biological Chemistry. ,vol. 287, pp. 26563- 26575 ,(2012) , 10.1074/JBC.M112.369918
Kerstin Gari, Chantal Décaillet, Alicja Z. Stasiak, Andrzej Stasiak, Angelos Constantinou, The Fanconi anemia protein FANCM can promote branch migration of Holliday junctions and replication forks. Molecular Cell. ,vol. 29, pp. 141- 148 ,(2008) , 10.1016/J.MOLCEL.2007.11.032