Functions and regulation of the multitasking FANCM family of DNA motor proteins
作者： Xiaoyu Xue , Patrick Sung , Xiaolan Zhao
关键词: Model organism 、 Gene duplication 、 Genome 、 G2-M DNA damage checkpoint 、 DNA repair 、 FANCM 、 Fanconi anemia 、 DNA replication 、 Biology 、 Genetics
摘要: Members of the conserved FANCM family DNA motor proteins play key roles in genome maintenance processes. supports duplication and repair under different circumstances also functions ATR-mediated damage checkpoint. Some these are shared among lower eukaryotic members. Human has been linked to Fanconi anemia, a syndrome characterized by cancer predisposition, developmental disorder, bone marrow failure. Recent studies on human its orthologs from other organisms have provided insights into their biological functions, regulation, collaboration with factors. This review summarizes progress made, goal providing an integrated view regulation enzymes humans model how they advance our understanding
sci-hub.se 参考文章(102)
Michael Primig, Roy M. Williams, Elizabeth A. Winzeler, Gela G. Tevzadze, Andrew R. Conway, Seung Y. Hwang, Ronald W. Davis, Rochelle Easton Esposito, The core meiotic transcriptome in budding yeasts Nature Genetics. ,vol. 26, pp. 415- 423 ,(2000) , 10.1038/82539
Dorina Saro, Hengyao Niu, Grzegorz Ira, Dana Branzei, Patrick Sung, Xiaolan Zhao, Xiaoyu Xue, Koyi Choi, Jaclyn N. Bonner, Barnabas Szakal, Yu-Hung Chen, Alma Papusha, Selective modulation of the functions of a conserved DNA motor by a histone fold complex Genes & Development. ,vol. 29, pp. 1000- 1005 ,(2015) , 10.1101/GAD.259143.115
Thiyam Ramsing Singh, Dorina Saro, Abdullah Mahmood Ali, Xiao-Feng Zheng, Chang-hu Du, Michael W. Killen, Aristidis Sachpatzidis, Kebola Wahengbam, Andrew J. Pierce, Yong Xiong, Patrick Sung, Amom Ruhikanta Meetei, MHF1-MHF2, a Histone-Fold-Containing Protein Complex, Participates in the Fanconi Anemia Pathway via FANCM Molecular Cell. ,vol. 37, pp. 879- 886 ,(2010) , 10.1016/J.MOLCEL.2010.01.036
Alejandro Chavez, Vishesh Agrawal, F. Brad Johnson, Homologous Recombination-dependent Rescue of Deficiency in the Structural Maintenance of Chromosomes (Smc) 5/6 Complex Journal of Biological Chemistry. ,vol. 286, pp. 5119- 5125 ,(2011) , 10.1074/JBC.M110.201608
Gérald Lossaint, Marion Larroque, Cyril Ribeyre, Nicole Bec, Christian Larroque, Chantal Décaillet, Kerstin Gari, Angelos Constantinou, FANCD2 Binds MCM Proteins and Controls Replisome Function upon Activation of S Phase Checkpoint Signaling Molecular Cell. ,vol. 51, pp. 678- 690 ,(2013) , 10.1016/J.MOLCEL.2013.07.023
T. R. Singh, A. M. Ali, V. Busygina, S. Raynard, Q. Fan, C.-h. Du, P. R. Andreassen, P. Sung, A. R. Meetei, BLAP18/RMI2, a novel OB-fold-containing protein, is an essential component of the Bloom helicase-double Holliday junction dissolvasome. Genes & Development. ,vol. 22, pp. 2856- 2868 ,(2008) , 10.1101/GAD.1725108
Min Huang, Jung Min Kim, Bunsyo Shiotani, Kailin Yang, Lee Zou, Alan D. D'Andrea, The FANCM/FAAP24 Complex Is Required for the DNA Interstrand Crosslink-Induced Checkpoint Response Molecular Cell. ,vol. 39, pp. 259- 268 ,(2010) , 10.1016/J.MOLCEL.2010.07.005
Nathan A. Ellis, Joanna Groden, Tian-Zhang Ye, Joel Straughen, David J. Lennon, Susan Ciocci, Maria Proytcheva, James German, The Bloom's syndrome gene product is homologous to RecQ helicases Cell. ,vol. 83, pp. 655- 666 ,(1995) , 10.1016/0092-8674(95)90105-1
Hui Yang, Tianlong Zhang, Ye Tao, Lijing Wu, Hong-tao Li, Jin-qiu Zhou, Chen Zhong, Jianping Ding, Saccharomyces Cerevisiae MHF Complex Structurally Resembles the Histones (H3-H4)2 Heterotetramer and Functions as a Heterotetramer Structure. ,vol. 20, pp. 364- 370 ,(2012) , 10.1016/J.STR.2011.12.012
Steven Raynard, Wendy Bussen, Patrick Sung, A Double Holliday Junction Dissolvasome Comprising BLM, Topoisomerase IIIα, and BLAP75 * Journal of Biological Chemistry. ,vol. 281, pp. 13861- 13864 ,(2006) , 10.1074/JBC.C600051200