Production of a Transmission Blocking Vaccine Candidate of Rodent Malaria Plasmodium Berghei Using a Baculovirus Expression Vector System
作者： J. Kobayashi , H. Matsuoka , Y. Chinzei , R. E. Sinden , S. Miyajima
DOI: 10.1007/978-94-011-0848-5_6
关键词:
摘要: An ookinete surface antigen Pbs21 of rodent malaria, Plasmodium berghei, was successfully produced in both cultured BmN4 cells as well the silkworm larvae using a baculovirus expression vector system Bombyx mori. The recombinant purified from larval hemolymph with an affinity column and used for immunization mice. Anti-native induced immunized mice transmission P. berghei to mosquito Anopheles stephensi strongly blocked these Immunoblotting analyses suggested that has structure close native is good candidate blocking vaccine malaria parasite.
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