Beta-amyloid deposition in chronic traumatic encephalopathy

摘要: Chronic traumatic encephalopathy (CTE) is a neurodegenerative disease associated with repetitive mild brain injury. It defined pathologically by the abnormal accumulation of tau in unique pattern that distinct from other tauopathies, including Alzheimer’s (AD). Although trauma has been suggested to increase amyloid β peptide (Aβ) levels, extent Aβ deposition CTE not thoroughly characterized. We studied heterogeneous cohort deceased athletes and military veterans neuropathologically diagnosed (n = 114, mean age at death 60) test hypothesis altered more severe pathology worse clinical outcomes. found deposition, either as diffuse or neuritic plaques, was present 52 % subjects. Moreover, occurred an accelerated rate dynamics compared normal aging population (OR 3.8, p < 0.001). also clear pathological dichotomy between those cases plaques without. significantly presence APOE e4 allele (p 0.035), older symptom onset 0.001), In addition, when controlling for age, were increased tauopathy stage (β 2.43, 0.018), co-morbid Lewy body 5.01, 0.009), dementia 4.45, 0.012). A subset subjects met diagnostic criteria both AD, these total levels Aβ1-40 depths cortical sulcus gyral crests. Overall, findings suggest progression independent age.