Polypathology and dementia after brain trauma: Does brain injury trigger distinct neurodegenerative diseases, or should they be classified together as traumatic encephalopathy?

摘要: Neuropathological studies of human traumatic brain injury (TBI) cases have described amyloid plaques acutely after a single severe TBI, and tau pathology repeat mild TBI (mTBI). This has helped drive the hypothesis that moderate to increases risk developing late-onset Alzheimer's disease (AD), while mTBI chronic encephalopathy (CTE). In this review we critically assess position-examining epidemiological case control studies, neuropathological evidence, preclinical data. Epidemiological emphasize is associated with increased multiple types dementia, not just AD-type can also trigger other neurodegenerative conditions such as Parkinson's disease. Further, post-mortem on both show combinations amyloid, tau, TDP-43, Lewy body indicating neuropathology best 'polypathology'. Preclinical confirm proteins development accumulate in TBI. The sequelae share common features clinical symptoms classically defined disorders. However, spectrum cognitive neurobehavioral disorders occur following viewed CTE, considered represent distinct diseases AD. These data support suggestion manifestations TBI-induced be classified together or trauma-induced neurodegeneration, regardless nature frequency precipitating