Treatment of Patients with Neuroectodermal Tumors by Monoclonal Ganglioside Antibodies

摘要: Serological probes have a long history in the study of cancer cells (1). Conventional serological analysis had to rely on polyclonal antibodies, which proved be drawback particular for characterization human cells. Polyclonal antisera might contain antibodies unrelated specificity addition disered antibody. A general procedure production monoclonal defined specificity, first described by Kohler and Milstein 1975 (2), revolutionized biochemical cancer. Monoclonal can recognize single antigenic determinant mixture antigens produced great quantities reproducible lots, permitting large scale practical applications. Applying this methodology number well characterized tumor restricted been (see reviews 3, 4), some them belonging structurally group glycolipids (5, 6). Gangliosides represent subgroup (GD3, GD2, GM2 according classification Svennerholm) are recognized as associated neuroectodermal tumors.