P2X(7) receptor at the heart of disease
作者： Ei Vasileiou , C M Turner , R M Montero , G Vergoulas
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摘要: Purinergic signaling is a crucial component of disease whose pathophysiological basis now well established. This review focuses on P2X(7), unique bifunctional purinoreceptor that either opens non selective cation channel or forms large, cytolytic pore depending agonist application and leading to membrane blebbing cell death by necrosis apoptosis.Activation P2X(7) receptor has been shown stimulate the release multiple proinflammatory cytokines activated macrophages, with IL-1b be most extensively studied among them. These findings were verified use knockout ((-/-)) mice.Update information coming from all fields research implicate this at very heart diseases such as rheumatoid arthritis, sclerosis, depression, Alzheimer disease, kidney damage, in renal fibrosis experimental nephritis.Clinical studies are currently underway newly developed antagonists for receptor, results which eagerly anticipated. together data in-vivo experiments mice in-vitro will shed light exciting area.
参考文章(117)
Philippe Bodin, Geoffrey Burnstock, Purinergic Signalling: ATP Release Neurochemical Research. ,vol. 26, pp. 959- 969 ,(2001) , 10.1023/A:1012388618693
Stylianos Antonarakis, A. Gos, F. Talabot, J. Lorenz, E. Lai, Michael Andréw Morris, G. N. Buell, GENE STRUCTURE AND CHROMOSOMAL LOCALIZATION OF THE HUMAN P2X7 RECEPTOR Receptors & Channels. ,vol. 5, pp. 347- 354 ,(1998)
Geoffrey Burnstock, Gillian E. Knight, Cellular distribution and functions of P2 receptor subtypes in different systems International Review of Cytology-a Survey of Cell Biology. ,vol. 240, pp. 31- 304 ,(2004) , 10.1016/S0074-7696(04)40002-3
T.H. Steinberg, S.C. Silverstein, Extracellular ATP4- promotes cation fluxes in the J774 mouse macrophage cell line. Journal of Biological Chemistry. ,vol. 262, pp. 3118- 3122 ,(1987) , 10.1016/S0021-9258(18)61477-2
K. Nieber, D. Eschke, A. Brand, Chapter 22 Brain hypoxia: Effects of ATP and adenosine Progress in Brain Research. ,vol. 120, pp. 287- 297 ,(1999) , 10.1016/S0079-6123(08)63563-3
Kristin A. Hogquist, Emil R. Unanue, David D. Chaplin, David D. Chaplin, Release of IL-1 from mononuclear phagocytes. Journal of Immunology. ,vol. 147, pp. 2181- 2186 ,(1991)
P Chiozzi, S Falzoni, D Ferrari, P Ricciardi-Castagnoli, M Villalba, F Di Virgilio, Mouse microglial cells express a plasma membrane pore gated by extracellular ATP Journal of Immunology. ,vol. 156, pp. 1531- 1539 ,(1996)
CA Dinarello, Biologic basis for interleukin-1 in disease Blood. ,vol. 87, pp. 2095- 2147 ,(1996) , 10.1182/BLOOD.V87.6.2095.BLOODJOURNAL8762095
Fabio Martinon, Kimberly Burns, Jürg Tschopp, The Inflammasome Molecular Cell. ,vol. 10, pp. 417- 426 ,(2002) , 10.1016/S1097-2765(02)00599-3
Francesco Di Virgilio, Paola Chiozzi, Davide Ferrari, Simonetta Falzoni, Juana M Sanz, Anna Morelli, Maurizia Torboli, Giorgio Bolognesi, O Roberto Baricordi, None, Nucleotide receptors: an emerging family of regulatory molecules in blood cells Blood. ,vol. 97, pp. 587- 600 ,(2001) , 10.1182/BLOOD.V97.3.587