Some Pharmacologic Considerations Concerning the Control of Acute Leukemia

摘要: Summary Studies on the mode of action presently useful anti-leukemic drugs describe metabolic features leukemic lymphoblasts which serve as a basis for killing these cells selectively. Individually, agents are inadequate in most cases to maintain prolonged remissions. The combined use, however, act differently has potentiality greatly increasing selectivity treatments and minimizing development drug resistance. In anticipation discovery more effective may displace these, or utilization new information about regulatory macromolecules, amplification effectiveness can be attempted, manner discussed, with derived from studies physiologic regulator (cortisol), pseudo-feedback inhibitor (6-mercaptopurine), vitamin antagonist (amethopterin).