Bio-accumulation of organic contaminants in Indo-Pacific humpback dolphins: Preliminary unique features of the brain and testes.
作者： Xian Sun , Fengping Zhan , Ri-Qing Yu , Laiguo Chen , Yuping Wu
DOI: 10.1016/J.ENVPOL.2020.115511
关键词:
摘要: Abstract There is little information about the residue levels and congener composition of organic contaminants (OCs) in cetaceans. In present study, we investigated polychlorinated biphenyls (PCBs), polycyclic aromatic hydrocarbons (PAHs) organochlorine pesticides (OCPs) blubber, blood, brain testes Indo-Pacific humpback dolphins (Sousa chinensis) stranded Pearl River Estuary (PRE), China. The lowest blubber/tissue partition coefficients were found for sum hexachlorocyclohexanes (ΣHCHs) ΣPAHs, while highest ΣPCBs dichlorodiphenyltrichloroethanes (ΣDDTs), likely attributing to octanol-water features. low OCs theoretically resulted from blood-brain barrier, blood-testes contaminant molecule dimensions unique lipid compositions testes. Compared with other contaminants, higher mean brain/blood testes/blood mirex, heptachlor, dieldrin endrin would increase risks associated exposure-related toxicity bioavailability within these tissues. Observations also suggest that as mobilizes may redistribute, leading elevated tissue (such brain) concentrations. Therefore, less blubber be more susceptible health risks. living PRE are at great risk due variety indirect contact non-target organisms, affecting animals (toxic effects accumulation). Our findings contribute knowledge potential exposure on developmental neurotoxicity reproductive damage marine mammals.
sci-hub.st 参考文章(73)
Sung Yong Eum, Dima Jaraki, Ibolya E. András, Michal Toborek, Lipid rafts regulate PCB153-induced disruption of occludin and brain endothelial barrier function through protein phosphatase 2A and matrix metalloproteinase-2. Toxicology and Applied Pharmacology. ,vol. 287, pp. 258- 266 ,(2015) , 10.1016/J.TAAP.2015.06.011
T. M. Brown, P. S. Ross, K. J. Reimer, Transplacental Transfer of Polychlorinated Biphenyls, Polybrominated Diphenylethers, and Organochlorine Pesticides in Ringed Seals (Pusa hispida) Archives of Environmental Contamination and Toxicology. ,vol. 70, pp. 20- 27 ,(2016) , 10.1007/S00244-015-0191-2
N. Jørgensen, M. Vierula, R. Jacobsen, E. Pukkala, A. Perheentupa, H. E. Virtanen, N. E. Skakkebaek, J. Toppari, Recent adverse trends in semen quality and testis cancer incidence among Finnish men International Journal of Andrology. ,vol. 34, ,(2011) , 10.1111/J.1365-2605.2010.01133.X
Alexey Goncharov, Robert Rej, Serban Negoita, Maria Schymura, Azara Santiago-Rivera, Gayle Morse, David O. Carpenter, , Lower serum testosterone associated with elevated polychlorinated biphenyl concentrations in Native American men. Environmental Health Perspectives. ,vol. 117, pp. 1454- 1460 ,(2009) , 10.1289/EHP.0800134
Dana Loomis, Kathryn Guyton, Yann Grosse, Fatiha El Ghissasi, Véronique Bouvard, Lamia Benbrahim-Tallaa, Neela Guha, Heidi Mattock, Kurt Straif, None, Carcinogenicity of lindane, DDT, and 2,4-dichlorophenoxyacetic acid The Lancet Oncology. ,vol. 16, pp. 891- 892 ,(2015) , 10.1016/S1470-2045(15)00081-9
Christian Sonne, Kim Gustavson, Frank F. Rigét, Rune Dietz, Morten Birkved, Robert J. Letcher, Rossana Bossi, Katrin Vorkamp, Erik W. Born, Gitte Petersen, Reproductive performance in East Greenland polar bears (Ursus maritimus) may be affected by organohalogen contaminants as shown by physiologically-based pharmacokinetic (PBPK) modelling Chemosphere. ,vol. 77, pp. 1558- 1568 ,(2009) , 10.1016/J.CHEMOSPHERE.2009.09.044
F. William Jones, Supercritical fluid extraction as a cleanup technique for gas chromatographic analysis of pesticides in wool wax Journal of Agricultural and Food Chemistry. ,vol. 45, pp. 2569- 2572 ,(1997) , 10.1021/JF960884Z
Hueiwang Anna Jeng, Liang Yu, Alteration of sperm quality and hormone levels by polycyclic aromatic hydrocarbons on airborne particulate particles. Journal of Environmental Science and Health Part A-toxic\/hazardous Substances & Environmental Engineering. ,vol. 43, pp. 675- 681 ,(2008) , 10.1080/10934520801959815
Letizia Marsili, Anna Caruso, M Cristina Fossi, Margherita Zanardelli, Elena Politi, Silvano Focardi, Polycyclic aromatic hydrocarbons (PaHs) in subcutaneous biopsies of Mediterranean cetaceans. Chemosphere. ,vol. 44, pp. 147- 154 ,(2001) , 10.1016/S0045-6535(00)00206-X
Liesbeth Weijs, Raymond S. H. Yang, Adrian Covaci, Krishna Das, Ronny Blust, Physiologically based pharmacokinetic (PBPK) models for lifetime exposure to PCB 153 in male and female harbor porpoises (Phocoena phocoena): model development and evaluation. Environmental Science & Technology. ,vol. 44, pp. 7023- 7030 ,(2010) , 10.1021/ES101688H