Injectable camptothecin conjugated hydrogels with simultaneous drug release and degradation

摘要: Hydrogels loaded with anticancer drugs can be regarded as depots for intratumoral chemotherapy to downsize tumors. However, the low drug loading content, rapid release, and subsequently undegraded blank hydrogel matrix may limit their applications. In this work, we prepared an injectable camptothecin (CPT) conjugated simultaneous release degradation resolve these problems. Poly[oligo(ethylene glycol) maleate] (POEGM) two terminal hydroxyl groups was first synthesized by direct polycondensation of oligo(ethylene (OEG) maleic acid (MA). CPT, a highly hydrophobic drug, chain end POEGM via carbonic ester bond. The resultant water-soluble CPT–polymer conjugate could in situ crosslinked poly[oligo(ethylene mercaptosuccinate] (POEGMS) rapidly through thiol-ene “click” reaction under physiological conditions, which used CPT hydrogels. Bright blue fluorescence emitted from CPT-conjugated UV lamp demonstrated homogeneity loading. breakage bond hydrogels bonds were observed simultaneously within one week 16 days, depending on solid content exhibited significant cytotoxicity HepG2 cells based vitro cell viability assays. As contrast, without conjugation showed excellent biocompatibility same conditions. This kind potential candidate intratumor delivery.