作者: Yevgeny Brudno , David J. Mooney
DOI: 10.1016/J.JCONREL.2015.09.011
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摘要: Stimuli-responsive polymeric depots capable of on-demand release therapeutics promise a substantial improvement in the treatment many local diseases. These systems have advantage controlling dosing so that payload is released at time and with dose chosen by physician or patient, can be varied as disease progresses healing occurs. Macroscale drug depot induced to through action physical stimuli such ultrasound, electric magnetic fields light well addition pharmacological nucleic acids small molecules. In this review, we highlight recent advances development engineered for releasing therapeutic molecules stimulation.