Distributions of Irritative Zones Are Related to Individual Alterations of Resting-State Networks in Focal Epilepsy.

摘要: Alterations in the connectivity patterns of fMRI-based resting-state networks (RSNs) have been reported several types epilepsies. Evidence pointed out these alterations might be associated with genesis and propagation interictal epileptiform discharges (IEDs). IEDs also evoke blood-oxygen-level dependent (BOLD) responses, which used to delineate irritative zones during preoperative work-up. Therefore, one may expect a relationship between topology IED-evoked BOLD response network altered spatial RSNs. In this study, we EEG recordings fMRI data obtained simultaneously from chronic model focal epilepsy Wistar rats verify our hypothesis. We found that comprise both cortical subcortical structures rat-dependent topology. all rats, activation deactivation responses. Using Granger causality method, many cases areas directed influences on (p<0.05). were able predict topological properties (i.e., focal/diffused, unilateral/bilateral) by performing hierarchical clustering analysis major features All results suggest disruptions RSNs previously humans different manifestations same transient events, probably reflecting consciousness. opinion, shutdown specific nodes default mode cause uncontrollable excitability other functionally connected brain areas. conclude responses deactivation) are intrinsically related, speculate an understanding their interplay is necessary discriminate epileptogenesis phenomena across modules via hub-based connectivity.