Towards Personalised Medicine in Childhood Acute Lymphoblastic Leukaemia
作者： Christina Halsey
DOI: 10.1159/000350349
关键词:
摘要: Childhood leukaemia is one of the success stories modern medicine. Initially advances were made by using progressively more intensive multi-agent chemotherapy regimens for all children. More recently, it has been appreciated that individual children differ considerably with respect to sensitivity their leukaemic cells and also susceptibility treatment-related toxicity. This led a move towards personalised treatment. The mainstay this approach use minimal residual disease measurement which assesses each patient's response initial therapy enables treatment modifications be in real time. Personalised approaches extend identifying at risk drug toxicity pharmacogenomics molecular techniques identify mutations can specifically targeted new drugs. article reviews strategies current speculates on how interpreting explosion genetic information becoming available may improve future.
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Donald Pinkel, Five-Year Follow-Up of "Total Therapy" of Childhood Lymphocytic Leukemia JAMA: The Journal of the American Medical Association. ,vol. 216, pp. 648- 652 ,(1971) , 10.1001/JAMA.1971.03180300032007
I-Ming Chen, Richard C. Harvey, Charles G. Mullighan, Julie Gastier-Foster, Walker Wharton, Huining Kang, Michael J. Borowitz, Bruce M. Camitta, Andrew J. Carroll, Meenakshi Devidas, D. Jeanette Pullen, Debbie Payne-Turner, Sarah K. Tasian, Shalini Reshmi, Catherine E. Cottrell, Gregory H. Reaman, W. Paul Bowman, William L. Carroll, Mignon L. Loh, Naomi J. Winick, Stephen P. Hunger, Cheryl L. Willman, Outcome modeling with CRLF2, IKZF1, JAK, and minimal residual disease in pediatric acute lymphoblastic leukemia: a Children's Oncology Group Study Blood. ,vol. 119, pp. 3512- 3522 ,(2012) , 10.1182/BLOOD-2011-11-394221
Kathryn G Roberts, Ryan D Morin, Jinghui Zhang, Martin Hirst, Yongjun Zhao, Xiaoping Su, Shann-Ching Chen, Debbie Payne-Turner, Michelle L Churchman, Richard C Harvey, Xiang Chen, Corynn Kasap, Chunhua Yan, Jared Becksfort, Richard P Finney, David T Teachey, Shannon L Maude, Kane Tse, Richard Moore, Steven Jones, Karen Mungall, Inanc Birol, Michael N Edmonson, Ying Hu, Kenneth E Buetow, I-Ming Chen, William L Carroll, Lei Wei, Jing Ma, Maria Kleppe, Ross L Levine, Guillermo Garcia-Manero, Eric Larsen, Neil P Shah, Meenakshi Devidas, Gregory Reaman, Malcolm Smith, Steven W Paugh, William E Evans, Stephan A Grupp, Sima Jeha, Ching-Hon Pui, Daniela S Gerhard, James R Downing, Cheryl L Willman, Mignon Loh, Stephen P Hunger, Marco A Marra, Charles G Mullighan, None, Genetic Alterations Activating Kinase and Cytokine Receptor Signaling in High-Risk Acute Lymphoblastic Leukemia Cancer Cell. ,vol. 22, pp. 153- 166 ,(2012) , 10.1016/J.CCR.2012.06.005
Richard C. Harvey, Charles G. Mullighan, I-Ming Chen, Walker Wharton, Fady M. Mikhail, Andrew J. Carroll, Huining Kang, Wei Liu, Kevin K. Dobbin, Malcolm A. Smith, William L. Carroll, Meenakshi Devidas, W. Paul Bowman, Bruce M. Camitta, Gregory H. Reaman, Stephen P. Hunger, James R. Downing, Cheryl L. Willman, Rearrangement of CRLF2 is associated with mutation of JAK kinases, alteration of IKZF1, Hispanic/Latino ethnicity, and a poor outcome in pediatric B-progenitor acute lymphoblastic leukemia Blood. ,vol. 115, pp. 5312- 5321 ,(2010) , 10.1182/BLOOD-2009-09-245944
Mel Greaves, Carlo C. Maley, Clonal evolution in cancer Nature. ,vol. 481, pp. 306- 313 ,(2012) , 10.1038/NATURE10762
Jonathan Zalevsky, Irene W. L. Leung, Sher Karki, Seung Y. Chu, Eugene A. Zhukovsky, John R. Desjarlais, David F. Carmichael, Chris E. Lawrence, The impact of Fc engineering on an anti-CD19 antibody: increased Fcγ receptor affinity enhances B-cell clearing in nonhuman primates Blood. ,vol. 113, pp. 3735- 3743 ,(2009) , 10.1182/BLOOD-2008-10-182048
C. G. Mullighan, L. A. Phillips, X. Su, J. Ma, C. B. Miller, S. A. Shurtleff, J. R. Downing, Genomic Analysis of the Clonal Origins of Relapsed Acute Lymphoblastic Leukemia Science. ,vol. 322, pp. 1377- 1380 ,(2008) , 10.1126/SCIENCE.1164266
Jinghui Zhang, Li Ding, Linda Holmfeldt, Gang Wu, Sue L Heatley, Debbie Payne-Turner, John Easton, Xiang Chen, Jianmin Wang, Michael Rusch, Charles Lu, Shann-Ching Chen, Lei Wei, J Racquel Collins-Underwood, Jing Ma, Kathryn G Roberts, Stanley B Pounds, Anatoly Ulyanov, Jared Becksfort, Pankaj Gupta, Robert Huether, Richard W Kriwacki, Matthew Parker, Daniel J McGoldrick, David Zhao, Daniel Alford, Stephen Espy, Kiran Chand Bobba, Guangchun Song, Deqing Pei, Cheng Cheng, Stefan Roberts, Michael I Barbato, Dario Campana, Elaine Coustan-Smith, Sheila A Shurtleff, Susana C Raimondi, Maria Kleppe, Jan Cools, Kristin A Shimano, Michelle L Hermiston, Sergei Doulatov, Kolja Eppert, Elisa Laurenti, Faiyaz Notta, John E Dick, Giuseppe Basso, Stephen P Hunger, Mignon L Loh, Meenakshi Devidas, Brent Wood, Stuart Winter, Kimberley P Dunsmore, Robert S Fulton, Lucinda L Fulton, Xin Hong, Christopher C Harris, David J Dooling, Kerri Ochoa, Kimberly J Johnson, John C Obenauer, William E Evans, Ching-Hon Pui, Clayton W Naeve, Timothy J Ley, Elaine R Mardis, Richard K Wilson, James R Downing, Charles G Mullighan, None, The genetic basis of early T-cell precursor acute lymphoblastic leukaemia Nature. ,vol. 481, pp. 157- 163 ,(2012) , 10.1038/NATURE10725
V H J van der Velden, A Hochhaus, G Cazzaniga, T Szczepanski, J Gabert, J J M van Dongen, Detection of minimal residual disease in hematologic malignancies by real-time quantitative PCR: principles, approaches, and laboratory aspects. Leukemia. ,vol. 17, pp. 1013- 1034 ,(2003) , 10.1038/SJ.LEU.2402922
Giovanni Cazzaniga, Maria Grazia Valsecchi, Giuseppe Gaipa, Valentino Conter, Andrea Biondi, Defining the correct role of minimal residual disease tests in the management of acute lymphoblastic leukaemia British Journal of Haematology. ,vol. 155, pp. 45- 52 ,(2011) , 10.1111/J.1365-2141.2011.08795.X