Sequestered naltrexone in sustained release morphine or oxycodone – a way to inhibit illicit use?

摘要: Introduction: Under the growing concern about prescription opioid misuse, abuse, addiction, tampering and diversion, stakeholders (e.g, governments, pharmaceutical companies health care providers) are developing formulations that they hope less attractive to those seeking misuse or abuse pain medications. However, these products must maintain their therapeutic effectiveness safety. Many abusers tamper with in an effort convert active ingredient into a form suitable for alternative more abuse-desirable routes of administration, such as snorting, inhaling injecting. Areas covered: A tamper-deterrent strategy is embed antagonists agonist formulation. Upon tampering, antagonist released binds receptors sufficient amount impede access agonist. This approach intended reduce subjective rewarding effects euphoria which prominent following swallowing dosage w...