摘要: The microenvironment in which cells reside vivo dictates their biological and mechanical functioning is associated with morphogenetic regenerative processes may find implications medicine tissue engineering. development of nano- micro-fabricated technologies, three-dimensional (3D) printing technique, biomimetic medical materials have enabled researchers to prepare novel advanced substrates mimicking the microenvironment. Most morphologies behaviors cells, including contact guidance cell bridges are observed but not perceived traditional two-dimensional (2D) culture system, emerged on those substrates. Using bridges, can span over surface maintain stability integrity tissue, as physiological processes, such wound healing, regeneration development. Compared guidance, has received increased attention investigated extensively, studies remain scarce. Therefore, this mini-review, we comprehensively summarized classified different kinds formed various highlighted possible biophysical mechanisms underlying bridge formation for implication fields engineering medicine.
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