摘要: The concomitantly variable codons hypothesis of DNA substitution argues that at any time only a fraction the in gene are capable accepting mutation. However, as mutations fixed some positions gene, sites potentially also change because changed functional constraints. This has been termed "covarion" or when model is applied to nucleotides, "covariotide" hypothesis. covarion-covariotide proven be remarkably difficult test. Here I examine covariotide for 11 genes using likelihood ratio show nine examined provides better explanation data than does not allow constraints over time.
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