Trazodone: alternative dose regimens and sleep.

摘要: In a double-blind trial, 146 depressed patients were allocated at random to treatment with the same daily dose (100 mg 150 mg) of trazodone administered either as divided doses twice or single night. Over trial period 6 weeks there was highly significant reduction in mean Hamilton Depression Rating Scale scores both groups, no differences between them. The completed 10 visual analogue scales concerned their depressive symptomatology, sleep patterns and daytime sequelae. Significant improvement recorded on all items only between-group difference being relation how tired patient felt during day, which significantly better night-time dosage Weeks 1 2. most finding study questionnaires by awakening again evening. Trazodone night when given dosage, improved sleep. During first week this effect for group. This early may be particularly useful providing psychological encouragement onset treatment.