Rates of study completion with single versus split daily dosing of antidepressants: a meta-analysis.

摘要: Objective: To examine the tolerability of single versus multiple daily dosing (SDD vs. MDD) antidepressant drugs in clinical practice. Method: Studies comparing antidepressants were reviewed. Since there no numeric data available on rates adverse events for SDD MDD arms, meta-analyses carried out to compare study completers (or drop-outs) with dosing. Results: The review process identified 22 studies meeting our inclusion criteria. This meta-analysis found difference or regime antidepressants. Conclusion: Our analysis gives us an estimation overall acceptability treatment and course, but has limited utility when compared events. Yet, present analyses suggest that which are significant enough result drop-outs, not more frequent than MDD. strategy does seem be advantageous obviously is disadvantageous compliance. Thus, a simplified regimen may practical increase success depression.