Towards optimal treatment with growth hormone in short children and adolescents: evidence and theses.

摘要: Treatment with growth hormone (GH) has become standard practice for replacement in GH-deficient children or pharmacotherapy a variety of disorders short stature. However, even today, the reported adult heights achieved often remain below normal range. In addition, treatment is expensive and may be associated long-term risks. Thus, discussion factors relevant achieving an optimal individual outcome terms growth, costs, risks required. present review, heterogenous approaches GH are discussed, considering parameters available evaluation short- outcomes at different stages treatment. This discourse introduces potential newly emerging prediction algorithms comparison to other more conventional planning response GH. rare such as those stature, decisions cannot easily deduced from personal experience. An interactive approach utilizing derived experience large cohorts patient required decision-making facilitate use Such should also lead avoiding unnecessary unresponsive individuals.