How connective tissues temporally process mechanical stimuli

摘要: Connective tissues have the capacity to adapt a changing mechanical environment. Considerable experimental evidence suggests, however, that respond only small portion of loads they experience and thus ignore majority load experience. Evidence suggests 'temporally process' these external signals in specific ways: 1) trigger-like manner after relatively few events or cycles loading; 2) some window strain magnitude; 3) exhibit refractory period response; 4) memory for previous stimuli. These characteristics do not necessarily mirror distinct cellular phenomena but rather reflect typical features theoretical models. The which temporally process can be explained by energy transfer over short periods time from matrix second messenger systems. Much input into connective during deformation is recovered, little 'lost' potentially transferable cells. Since evolutionary principles suggest pathway response needs defined biologically optimal use energy, it logical cells would evolved mechanisms finite level integrated stimuli order rapidly (fitness) especially times environmental duress.