Failure of systemic antibiotics to eradicate gram-negative bacilli from the airway of mechanically ventilated very low-birth-weight infants.

摘要: Abstract Background: Gram-negative bacillary (GNB) airway colonization in mechanically ventilated newborns is associated with morbidity and mortality, which may be reduced if systemic antimicrobial therapy eradicates GNB from the airway. Efforts to do so adults have met variable success; similar experiences not been reported. Methods: From 1991 through 1998, 531 very low–birth-weight infants were longer than 2 weeks. The study group was 106 colonization. Sixty-four other neonates whom nosocomial bloodstream infections developed served as antibiotic treatment outcome control. Results: Isolated enteric (70 cases) environmental (36 GNB. Gentamicin alone or ceftazidime (79), (11), piperacillin combination tazobactam tobramycin (8), tobramycin, ampicillin/sulbactam mezlocillin (8) antimicrobials selected. Systemic antibiotics failed eradicate 97% of cases. Six died for reasons unrelated infection. experienced 67 a result (53) (14) (23), (26), clindamycin (9), (3) (6) Survival occurred 84% infections. Conclusions: consistently newborns, therefore its empirical use prophylaxis should discouraged. (AJIC Am J Infect Control 2000;28:286-90)