Estradiol Increases IL-8 Secretion of Normal Human Breast Tissue and Breast Cancer In Vivo
作者： Christina Bendrik , Charlotta Dabrosin
DOI: 10.4049/JIMMUNOL.182.1.371
关键词:
摘要: IL-8 or CXCL8 has been associated with tumor angiogenesis, metastasis, and poor prognosis in breast cancer. Estrogen is crucial carcinogenesis progression. Whether sex steroids affect secretion of normal tissue cancer not known. Several cell types a secrete IL-8. Hence, regulatory mechanisms need to be investigated whole tissue. We used microdialysis sample human situ pre- postmenopausal women, preoperatively cancers experimental mice. found significant positive correlation between estradiol hormone-dependent vivo. Ex vivo, exposure increased the culture. In cancer, whereas anti-estrogen tamoxifen inhibited both vitro extracellularly vivo tumors nude An anti-IL-8 Ab endothelial proliferation induced by produced low levels exhibited decreased angiogenesis. Our results strongly suggest that critical role regulation may present novel therapeutic target for estrogen driven
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