Tamoxifen inhibits secretion of vascular endothelial growth factor in breast cancer in vivo.

摘要: Vascular endothelial growth factor (VEGF) is considered a key mediator of tumor angiogenesis, including neovascularization in human breast cancer. High tissue VEGF levels appear to correlate with poor prognosis and decreased overall survival node-positive node-negative cancer patients. Hormonal regulation expression has been demonstrated, some reports indicate that tamoxifen, partial estrogen receptor agonist, increases mRNA cells. These results contradict the efficacy tamoxifen as an adjuvant for estrogen-dependent cancer, yet clinical data show prevents metastasis survival. In this study, we confirmed previous studies showing intracellular vitro increased response similar those observed after treatment. To further study hormonal effects on release VEGF, used microdialysis sample extracellular space, where biologically active, solid tumors situ. We first time vivo MCF-7 nude mice. findings were cell culture medium was significantly by Furthermore, illustrate viable method may be applied detect soluble situ released tumor.