Self-injection of apomorphine in the rat: Positive reinforcement by a dopamine receptor stimulant
作者： Bruce L. Baxter , Melvin I. Gluckman , Larry Stein , Rosemary A. Scerni
DOI: 10.1016/0091-3057(74)90085-9
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摘要: Abstract Rats with jugular cannulas self-administer the dopamine receptor stimulant apomorphine at doses from 0.125 to 1 mg/kg/injection. Pretreatment blocker pimozide (0.5 or mg/kg) disrupted self-injection of apomorphine. These data support idea that activation receptors yields positive reinforcement, although other neurochemical actions have not been ruled out. Dopaminergic mechanisms may also be involved in self-administration psychomotor stimulants and narcotics.
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