The globular heads of C1q specifically recognize surface blebs of apoptotic vascular endothelial cells.

作者: Jeannine S. Navratil , Simon C. Watkins , Jeffrey J. Wisnieski , Joseph M. Ahearn

DOI: 10.4049/JIMMUNOL.166.5.3231

关键词:

摘要: Complement protein C1q is required to maintain immune tolerance. The molecular mechanism responsible for this link has not been determined. We have previously demonstrated that binds directly and specifically surface blebs of apoptotic human keratinocytes, suggesting it may participate in clearance self Ags generated during programmed cell death. Here, we demonstrate also vascular endothelial cells PBMC. These are recognized by the globular heads C1q, which bind blebs, deposition increases as mature on surface. observations suggest from circulation walls lumen. interaction with suggests be capable activating classical pathway complement under certain circumstances, generating C4- C3-derived ligands receptors such CR1, CR2, CR3, CR4. Appropriate recognition targeted contents critical maintenance

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