Fluid volume compartments and biochemical measurements for disclosing fluid depletion during actue and rigorous bed rest in normal subjects

摘要: Rigorous bed rest (RBR) induces fluid depletion, however, little isknown about the mechanisms of development depletion duringacute (ABR). Measuring retention and body hydrationparameters, aim this study was to establish whether ABR than RBRcould depress significantly more contributing greaterfluid development. Studies were conducted during pre rest(BR) period three days seven RBR.Thirty normal male individuals aged, 24.2 ± 5.0 years chosen assubjects. They divided into groups: unrestricted ambulatorycontrol subjects (UACS), acute rested (ABRS) rigorousbed (RBRS). Acute confined abruptlyto RBR, while they did not have any prior knowledge exact dateand time when would be asked stay in bed. restedsubjects submitted RBR on a predetermined date known themright from start study. Unrestricted ambulatory controlsubjects type rest. Fluid loss, urinaryand plasma sodium (Na+) potassium(K+), urinary osmolality osmolality, wholeblood hematocrit (Hct), whole blood hemoglobin (Hb), total plasmaprotein increased (p < 0.05) with time, whilefluid retention, extracellular volume (ECV), (PV), redcell (RCV), (BV), interstitial (IV) fluidintakes reduced ABRSand RBRS compared their pre-BR values control values(UACS). However, measured parameters changed significantly(p ABRS RBRS. rention,fluid intake, Na+ andK+, Hct, Hb, protein, plasmaosmolality, ECV, PV, RCV, BV IV change UACS withtheir values. It concluded that significant increase ofurinary Hct plasmaprotein, K+, andsignificant decrease BV, may demonstrate fluiddepleteion, higher loss spite fluiddepletion show decreased retention. Dissociation between fluidlosses suggest presence impair fluidretention as mechanism depletion.