Targeting of Lymphotoxin-α to the Tumor Elicits an Efficient Immune Response Associated with Induction of Peripheral Lymphoid-like Tissue
作者： David Schrama , Per thor Straten , Wolfgang H. Fischer , Alexander D. McLellan , Eva-Bettina Bröcker
DOI: 10.1016/S1074-7613(01)00094-2
关键词:
摘要: A recombinant antibody-lymphotoxin-alpha fusion protein induced an adaptive immune response protecting mice from melanoma. Importantly, this elicited the formation of a lymphoid-like tissue in tumor microenvironment containing L-selectin+ T cells and MHC class II+ antigen-presenting cells, as well B cell aggregates. Furthermore, PNAd+/TCA4+ high endothelial venules were observed within tumor, suggesting entry channels for naive infiltrates. Over course therapy, marked clonal expansion certain TCR specificities occurred among tumor-infiltrating lymphocytes that displayed reactivity against melanoma TRP-2(180-188) peptide. Consequently, may have been recruited to primed expanded by lymphotoxin-alpha at site.
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