Platelet consumption in thrombocythemia complicated by erythromelalgia: reversal by aspirin.

摘要: The involvement of platelets in the pathogenesis erythromelalgia, a frequent and characteristic microvascular thrombotic manifestation patients with primary thrombocythemia polycythemia rubra vera, was investigated by measuring survival turnover 51Cr labeled autologous 10 complicated asymptomatic 6 subjects reactive thrombocytosis. mean platelet time erythromelalgia 4.2 +/- 0.2 days, which is significantly decreased as compared (6.6 0.3 p < 0.001) thrombocytosis (8.0 0.4 0.001). (p 0.01) patients. Treatment aspirin increased from 4.0 days to 6.9 associated an elevation count 216 30 x 10(9) per liter Coumadin failed improve or symptoms caused erythromelalgia. consumption attributed formation thrombi arterial microvasculature. This conclusion supported ability interrupt clinical features