Healing of rabbit calvarial bone defects using biphasic calcium phosphate ceramics made of submicron‐sized grains with a hierarchical pore structure
作者： Jin-Woo Park , Eun-Suk Kim , Je-Hee Jang , Jo-Young Suh , Kwang-Bum Park
DOI: 10.1111/J.1600-0501.2009.01846.X
关键词:
摘要: Objectives: This study investigated the efficacy of new bone graft substitutes – biphasic calcium phosphates (BCP) made submicron-sized grains with fully interconnected wide-range micron-scale pores in two different macrodesigns: donut shaped a 300–400 μm central macropore (n-BCP-1) or rod-shaped (n-BCP-2) healing rabbit calvarial defects, and compared their bone-healing properties those various commercial substitutes, which included similar BCP composition (MBCP Osteon), anorganic bovine (Bio-Oss), β-TCP (Cerasorb). Material methods: The surface morphology was using scanning electron microscopy (SEM). Defects 8 mm diameter were created calvaria 30 adult male New Zealand White rabbits filled six types substitutes. percentage newly formed (NB%) evaluated histomorphometrically 4 8 weeks after implantation. Results: SEM observation showed micropore structures n-BCP-1 n-BCP-2 groups; these groups also considerable formation inner micropores as well on outer surfaces. group exhibited enhanced direct ingrowth tissue blood vessels into pores. Histomorphometric analysis significantly greater NB% when other at (P<0.05). Conclusion: A ceramics hierarchical pore structure an effective osteoconductive material for treatment osseous defects calvaria. To cite this article: Park J-W, Kim E-S, Jang J-H, Suh J-Y, Park K-B, Hanawa T. Healing phosphate structure. Clin. Oral Impl. Res. 21, 2010; 268–276. doi: 10.1111/j.1600-0501.2009.01846.x
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