Characteristics of carbapenem-resistant Pseudomonas aeruginosa strains in patients with ventilator-associated pneumonia in intensive care units.

摘要: The aim of this study was to determine the characteristics carbapenem-resistant Pseudomonas aeruginosa (P. aeruginosa) strains and 5-year changes in resistance a tertiary university hospital. Material Methods. included 90 101 randomly selected P. serotyped 2003 2008, respectively. standardized disk diffusion test E-test were used antibiotics. considered have high-level if minimum inhibitory concentration (MIC) for imipenem or meropenem >32 μg/mL. To identify serogroups, sera containing specific antibodies against O group antigens used. isolates resistant or/and screened metallo-β-lactamase (MBL) production by using MBL E-test. Results. Comparison carbapenems within period revealed that level increased. In 2003, 53.3% found be highly imipenem, while percentage increased 87.8% (P=0.01). prevalence MBL-producing from 15.8% 61.9% 2008 (P<0.001). more often ciprofloxacin gentamicin than carbapenem-sensitive strains. carbapenem- additionally ceftazidime, cefepime, aztreonam, piperacillin, amikacin belonged O:11 serogroup MBL-non-producing (51.7% vs. 34.3%, P<0.05). A greater non-MBL-producing had low MICs as compared with Conclusions. results our emphasize need restrict spread usage treat infections intensive care units hospital