Appropriate and timely empirical antimicrobial treatment of icu infections--a role for carbapenems.

摘要: Treatment of serious nosocomial infections in the intensive care unit requires swift, effective, well-tolerated and appropriate therapy from outset. The consequences inappropriate treatment, i.e. use antibiotics that are ineffective against causative pathogen(s) or delayed therapy, numerous impact negatively upon both patient ever-dwindling healthcare resources many hospitals. Although have revolutionised treatment infections, their untimely within setting has led to emergence spread antibiotic-resistant bacteria worldwide. Consequently, ensure successful outcomes (reduce morbidity mortality), it is important any antibiotic employed right first time. an empirical stratagem providing broad-spectrum coverage a wide range suspected difficult-to-treat pathogens such as Pseudomonas aeruginosa. However, prevent errors past, this needs be tailored soon pathogen been identified resistance patterns known. carbapenems potent parenteral antibiotics, with ultra-broad spectrum activity encompasses multi-drug resistant Gram-negative bacteria. Clinical trial data supports clinical effectiveness these agents patients difficult treat pathogens.