Structural RNA has lower folding energy than random RNA of the same dinucleotide frequency

摘要: We present results of computer experiments that indicate several RNAs for which the native state (minimum free energy secondary structure) is functionally important (type III hammerhead ribozymes, signal recognition particle RNAs, U2 small nucleolar spliceosomal certain riboswitches, etc.) all have lower folding than random same length and dinucleotide frequency. Additionally, we find whole mRNA as well 5′-UTR, 3′-UTR, cds regions energies comparable to RNA, although there may be a statistically insignificant trace in 3′-UTR regions. Various authors used nucleotide (approximate) pattern matching computation minimum filters detect potential ESTs genomes. introduce new concept asymptotic Z-score describe fast, whole-genome scanning algorithm compute Z-scores moving-window contents. Asymptotic computations offer another filter, along with computations, functional genomic