Significance of extra 18q- chromosome in Japanese t(14;18)-positive lymphoma.
作者： H Yamabe , M Abe , H Wakasa , S Fukuhara , H Ohno
DOI: 10.1182/BLOOD.V71.6.1748.1748
关键词:
摘要: Karyotype evolution of t(14;18)-positive lymphoma was studied in 13 Japanese patients. The extra 18q- chromosome, found six ten patients with complex karyotypes, the most common change subsequent to a t(14;18)(q32;q21) chromosome translocation. additional interpreted as being duplication an derived from t(14;18). had transformed histology follicular small cleaved cell or diffuse large lymphoma, and five them extranodal expansion associated poor prognosis. These findings indicate that 18q-, together other abnormalities, is closely advanced grade disease evolutionally comparable second Philadelphia (Ph1) often blastic phase chronic myelocytic leukemia carrying t(9;22)(q34;q11). In addition, since rarely American there appears be difference karyotype between
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