Genetics and Genomics of Human Population Structure

摘要: Recent developments in sequencing technology have created a flood of new data on human genetic variation, and this has yielded insights into population structure. Here we review what both early more recent studies taught us about structure history. Early showed that most variation occurs within populations rather than between them, genetically related often cluster geographically. based much larger sets recapitulated these observations, but also demonstrated high-density genotyping allows individuals to be reliably assigned their origin. In fact, for admixed individuals, even the ancestry particular genomic regions can inferred. offered detailed information composition specific from around world, revealing how history shaped makeup. We briefly quantitative models history, including role natural selection played shaping variation.