The genome-wide patterns of variation expose significant substructure in a founder population.

摘要: Although high-density SNP genotyping platforms generate a momentum for detailed genome-wide association (GWA) studies, an offshoot is new insight into population genetics. Here, we present example in one of the best-known founder populations by scrutinizing ten distinct Finnish early- and late-settlement subpopulations. By determining genetic distances, homozygosity, patterns linkage disequilibrium, demonstrate that substructure, even individual ancestry, detectable at very high resolution supports concept multiple historical bottlenecks resulting from consecutive effects. Given studies are currently aiming identifying smaller effects, recognizing controlling substructure this fine level becomes imperative to avoid confounding spurious associations. This study provides power GWA data sets stratification caused history within seemingly homogeneous population, like Finns. Further, results provide interesting lessons concerning impact on genome landscape humans, as well approaches identify rare variants enriched these