摘要: 8 INTRODUCTION 9 REVIEW OF THE LITERATURE 10 1 Cancer as a genetic disease 1.1 General features of cancer genes 11 1.1.1 Oncogenes 1.1.2 Tumor suppressor 12 1.2 Inherited predisposition to 13 1.2.1 syndromes 14 1.2.2 Other forms cancer-predisposing variation 2 The era large-scale genome sequencing 16 2.1 Human genomic 2.2 Novel insights into 17 2.3 landscapes 18 3 Colorectal 19 3.
参考文章(246)
Hanan Lamlum, Mohammad Ilyas, Andrew Rowan, Susan Clark, Victoria Johnson, Jennie Bell, Ian Frayling, Jason Efstathiou, Kevin Pack, Stewart Payne, Rebecca Roylance, Patricia Gorman, Denise Sheer, Kay Neale, Robin Phillips, Ian Talbot, Walter Bodmer, Ian Tomlinson, The type of somatic mutation at APC in familial adenomatous polyposis is determined by the site of the germline mutation: a new facet to Knudson's 'two-hit' hypothesis. Nature Medicine. ,vol. 5, pp. 1071- 1075 ,(1999) , 10.1038/12511
Bert Vogelstein, Kenneth W. Kinzler, Yasmin Beazer-Barclay, Kelly J. Smith, Stanley R. Hamilton, Daniel B. Levy, Inactivation of Both APC Alleles in Human and Mouse Tumors Cancer Research. ,vol. 54, pp. 5953- 5958 ,(1994)
James R. Howe, Jennifer L. Bair, Mohamed G. Sayed, Mary E. Anderson, Frank A. Mitros, Gloria M. Petersen, Victor E. Velculescu, Giovanni Traverso, Bert Vogelstein, Germline mutations of the gene encoding bone morphogenetic protein receptor 1A in juvenile polyposis Nature Genetics. ,vol. 28, pp. 184- 187 ,(2001) , 10.1038/88919
Lawrence A. Loeb, Mutator Phenotype May Be Required for Multistage Carcinogenesis Cancer Research. ,vol. 51, pp. 3075- 3079 ,(1991)
Yardena Samuels, Victor E. Velculescu, Oncogenic Mutations of PIK3CA in Human Cancers Cell Cycle. ,vol. 3, pp. 1221- 1224 ,(2004) , 10.4161/CC.3.10.1164
Leena Peltonen, Aarno Palotie, Kenneth Lange, Use of population isolates for mapping complex traits Nature Reviews Genetics. ,vol. 1, pp. 182- 190 ,(2000) , 10.1038/35042049
Osamu Tetsu, Frank McCormick, Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells. Nature. ,vol. 398, pp. 422- 426 ,(1999) , 10.1038/18884
Rosann A. Farber, Jayne C. Boyer, Mutation rate of a microsatellite sequence in normal human fibroblasts Cancer Research. ,vol. 58, pp. 3946- 3949 ,(1998)
Christopher I Amos, Deeksha Bali, Tracy J Thiel, Joshua P Anderson, Ian Gourley, Marsha L Frazier, Patrick M Lynch, Martin A Luchtefeld, Alicia Young, Thomas J McGarrity, Michael F Seldin, None, Fine Mapping of a Genetic Locus for Peutz-Jeghers Syndrome on Chromosome 19p Cancer Research. ,vol. 57, pp. 3653- 3656 ,(1997)
P. Alberici, R. Fodde, The role of the APC tumor suppressor in chromosomal instability. Genome dynamics. ,vol. 1, pp. 149- 170 ,(2006) , 10.1159/000092506