Role of Biochemical Investigations and Diagnostic Tools in Detection of Adverse Drug Reactions

摘要: Aim of Study: To evaluate the role biochemical investigations (BI) and diagnostic tools (DT) in ADR detection. Materials Methods: An observational prospective cross-sectional study was done using suspected data collection form. Results: A total 2381 related events were recorded two years. Total number/percentage abnormalities (BA) detection rate 14.57% DT 1.091% contrast to 84.33% with clinical presentation. Maximum cases inward patients (87.13%), 67.02% by active surveillance. at one point & on follow up 56.31% Vs 46.38%. ECG, endoscopy, X-ray 0.57%, 0.22%, 0.22% CT scan, MRI, DEXA USG biopsy 0.04% each. ADRs severe/serious, latent Type-A nature. Anemia (4.6%), followed liver dysfunction (2.8%), renal dysfunction, electrolyte imbalance, hyperglycemia (1.1% each), abnormal coagulation profile (1%), decrease platelet count (0.8%), hypoglycemia (0.7%) most common BAs. Anti retroviral drugs (ART), tirofiban methotrexate accounted for anemia, ART anti tubercular insulin hypoglycemia, tirofiban, paclitaxel, capecipabine ifosfamide thrombocytopenia, hematuria enoxaparin dyslipidemia ADRs. Conclusion: BI can play very important detection.