Effect of Nonspecific Binding to Plasma Proteins on the Antithrombin Activities of Unfractionated Heparin, Low-Molecular-Weight Heparin, and Dermatan Sulfate
作者： Benilde Cosmi , James C. Fredenburgh , Janice Rischke , Jack Hirsh , Edward Young
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摘要: Background Nonspecific binding to plasma proteins decreases the anti–factor Xa (anti-Xa) activity of unfractionated heparin (UFH) but not that low-molecular-weight (LMWH). However, could influence anti-thrombin (anti-IIa) LMWH. To explore this possibility, we compared effects on anti-IIa activities UFH and We also examined their dermatan sulfate (DS) because, like UFH, DS binds proteins. Methods Results There was almost complete recovery when LMWH, or added from each 20 healthy volunteers. The addition a chemically modified with low affinity for antithrombin III containing increased in concentration-dependent fashion by displacing In contrast, low-affinity had no effect LMWH does bind proteins...
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