Histogenesis of the human adrenal medulla. An evaluation of the ontogeny of chromaffin and nonchromaffin lineages.

摘要: The authors previously evaluated the expression of a panel chromaffin-related genes during histogenesis human adrenal medulla. In these studies, chromaffin and nonchromaffin neuroblasts were identified. To better characterize neuroblasts, two additional markers: HNK-1, an antibody recognizing migratory neural crest cell; S-100, protein expressed by sustentacular cells HNK-1 immunoreactivity was found in both cell types at different times development, marking lineage second trimester gestation as well neonatal period. addition, S-100 noted some first identified approximately 28 weeks gestational age. These data suggest model medullary that incorporates chromaffin, ganglionic, lineages known to constitute adult