Stereoselective and Modular Assembly Method for Heterocycle-Fused Daucane Sesquiterpenoids.
作者： Mien Christiaens , Jan Hullaert , Kristof Van Hecke , Duchan Laplace , Johan M. Winne
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摘要: A stereoselective synthetic method is reported for the molecular framework found in common daucane and isodaucane sesquiterpenoid natural products. The constitutes a scalable, modular, also asymmetric access to complex product scaffold, wherein substitution pattern stereochemistry can be adjusted simply by choosing different starting materials. allows rapid introduction of diverse heterocyclic substructures such as (benzo)furans, (benzo)thiophenes, dithiins, thiazoles, indoles, which actually facilitate direct key intramolecular annulation step.
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