Compound 1-(3-(2-pyridyldithio)propionamido)-12-(5-hydrazidoglutaramido)-4,9-dioxadodecane

摘要: Bifunctional chemicals useful for linking aldehyde containing moieties to functionalities which are or can be reactive with sulfhydryl claimed and have the formula: L--S--(CH.sub.2).sub.n1 --CONH--SPACER--NH--X wherein L is a leaving group selected from --H --S--Ar, Ar represents optionally substituted phenyl pyridyl; n 1 =2-4; X from: --CO--Y--CONHNH 2 , hydrazide; ##STR1## hydrazine; ##STR2## --CO--Y--NH--CONHNH semicarbazide; --CO--Z--NH--CSNHNH thiosemicarbazide; Y alkylene oxaalkylene Z polypeptide residue bridging N-terminal amino C-terminal carboxy thereof; SPACER hydroxyl specifically includes residues having formulas --(CH.sub.2).sub.n2 --O--(CH.sub.2).sub.n2 --(a) each n2 independently 2-4 ##STR3## n3 2-6. Also hydrazides, semicarbazides, thiosemicarbazides of ω-mercaptocarboxylic acids lack diamine.