In vitro effects of propofol on gravid human myometrium.

摘要: The aim of this study was to evaluate the direct effect propofol (di-isopropyl phenol) on contractile properties gravid human uterine muscle. Six specimens muscle were obtained from term parturients undergoing elective lower segment caesarean section. Small strips (1 x 2 12 mm) prepared and suspended in an organ bath containing oxygenated Kreb's solution at 36.5 degrees C. Following preparation, spontaneous regular contractions developed a rate one contraction every six 10 minutes. Force recorded continuously using isometric tension transducer baseline measurements, introduced into concentrations corresponding microg/ml, 5 mcirog/ml 8 mirog/ml. also exposed intralipid equivalent that found microg/ml determine whether additive influenced contractility. Contractility (defined as area under tension/time curve) decreased 89 +/- 6.5% control 53 4.3% 45 4.1% microg/ml. This decrease contractility statistically significant >2 Intralipid did not significantly affect results show decreases isolated dose-dependent manner