Characterization of DNA Methylation in Circulating Tumor Cells
作者： Constantin Pixberg , Wolfgang Schulz , Nikolas Stoecklein , Rui Neves
DOI: 10.3390/GENES6041053
关键词:
摘要: Epigenetics contributes to molecular mechanisms leading tumor cell transformation and systemic progression of cancer. However, the dynamics epigenetic remodeling during metastasis remains unexplored. In this context, circulating cells (CTCs) might enable a direct insight into relevant for by providing access CTCs can be used as prognostic markers in cancer patients are regarded potential metastatic precursor cells. despite substantial technical progress, detection characterization remain challenging, particular analysis DNA methylation. As recent studies have started address state CTCs, we discuss here such investigations elucidate develop biomarkers.
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