Cilia loss sensitizes cells to transformation by activating the mevalonate pathway

Safdar Jawaid, Heather Seidle, Monica Gertz, Jamie Cheung, Carlin Corsino, Robin D. Couch, Human hydroxymethylglutaryl-coenzyme A reductase (HMGCR) and statin sensitivity Indian Journal of Biochemistry & Biophysics. ,vol. 47, pp. 331- ,(2010)

Peter E. Lipsky, Jennifer A. Cuthbert, Suppression of the Proliferation of Ras-transformed Cells by Fluoromevalonate, an Inhibitor of Mevalonate Metabolism Cancer Research. ,vol. 55, pp. 1732- 1740 ,(1995)

Rushika M. Perera, Svetlana Stoykova, Brandon N. Nicolay, Kenneth N. Ross, Julien Fitamant, Myriam Boukhali, Justine Lengrand, Vikram Deshpande, Martin K. Selig, Cristina R. Ferrone, Jeff Settleman, Gregory Stephanopoulos, Nicholas J. Dyson, Roberto Zoncu, Sridhar Ramaswamy, Wilhelm Haas, Nabeel Bardeesy, Transcriptional control of autophagy-lysosome function drives pancreatic cancer metabolism. Nature. ,vol. 524, pp. 361- 365 ,(2015) , 10.1038/NATURE14587

Aleksandra A. Pandyra, Peter J. Mullen, Carolyn A. Goard, Elke Ericson, Piyush Sharma, Manpreet Kalkat, Rosemary Yu, Janice T. Pong, Kevin R. Brown, Traver Hart, Marinella Gebbia, Karl S. Lang, Guri Giaever, Corey Nislow, Jason Moffat, Linda Z. Penn, Genome-wide RNAi analysis reveals that simultaneous inhibition of specific mevalonate pathway genes potentiates tumor cell death Oncotarget. ,vol. 6, pp. 26909- 26921 ,(2015) , 10.18632/ONCOTARGET.4817

J. W. Clendening, A. Pandyra, P. C. Boutros, S. E. Ghamrasni, F. Khosravi, G. A. Trentin, A. Martirosyan, A. Hakem, R. Hakem, I. Jurisica, L. Z. Penn, Dysregulation of the mevalonate pathway promotes transformation Proceedings of the National Academy of Sciences of the United States of America. ,vol. 107, pp. 15051- 15056 ,(2010) , 10.1073/PNAS.0910258107

Na Xu, Ning Shen, XiuXing Wang, Shan Jiang, Bin Xue, ChaoJun Li, Protein prenylation and human diseases: a balance of protein farnesylation and geranylgeranylation Science China Life Sciences. ,vol. 58, pp. 328- 335 ,(2015) , 10.1007/S11427-015-4836-1

Heidrun Karlic, Roman Thaler, Christopher Gerner, Thomas Grunt, Katharina Proestling, Florian Haider, Franz Varga, Inhibition of the mevalonate pathway affects epigenetic regulation in cancer cells Cancer Genetics and Cytogenetics. ,vol. 208, pp. 241- 252 ,(2015) , 10.1016/J.CANCERGEN.2015.03.008

James P. Bridges, Angelica Schehr, Yanhua Wang, Liya Huo, Valérie Besnard, Machiko Ikegami, Jeffrey A. Whitsett, Yan Xu, Epithelial SCAP/INSIG/SREBP Signaling Regulates Multiple Biological Processes during Perinatal Lung Maturation PLoS ONE. ,vol. 9, pp. e91376- ,(2014) , 10.1371/JOURNAL.PONE.0091376

Madeline A. Lancaster, Jana Schroth, Joseph G. Gleeson, Subcellular spatial regulation of canonical Wnt signalling at the primary cilium. Nature Cell Biology. ,vol. 13, pp. 700- 707 ,(2011) , 10.1038/NCB2259

Edward J. Michaud, Bradley K. Yoder, The Primary Cilium in Cell Signaling and Cancer: Figure 1. Cancer Research. ,vol. 66, pp. 6463- 6467 ,(2006) , 10.1158/0008-5472.CAN-06-0462