Statin Therapy Is Associated with Decreased Small, Dense Low-Density Lipoprotein Levels in Patients Undergoing Peritoneal Dialysis

摘要: Cardiovascular disease is a major cause of morbidity and mortality among hemodialysis (HD) peritoneal dialysis (PD) patients, dyslipidemia plays an important role in its pathogenesis. In particular, small, dense LDL (sd-LDL) particles have been recently highlighted as emerging cardiovascular risk factor. PD patients exhibit more overtly abnormal lipid profile than HD probably due to the metabolic interference fluid. Statins are main drugs for treatment they able decrease all subclasses levels, but it remains unclear whether can influence proportion sd-LDL. Only few studies regarding effect statins on these performed and, our knowledge, no trials carried out patients. Therefore, we compared sd-LDL two populations Our study suggests that statin therapy may be effective reducing both absolute amount with profile, such undergoing dialysis. do not seem altering levels other factors subtractions generation, hypertension diabetes mellitus. If when results prove reproducible large-scale studies, should provide new insights into actual atherogenesis or