Tolerance to lactose among lactase-deficient American Indians

摘要: Abstract To determine the amount of lactose that could be tolerated in a meal, 59 lactasedeficient American Indians, ranging age from 5 to 62, were given graded doses lactose. The diagnosis lactase deficiency had been documented previously by showing increased breath hydrogen after an oral load (2 g per kg, maximum 50 g). With this load, 88% subjects symptoms. On 6 consecutive mornings, each subject was breakfast contained 0 18 g. order breakfasts randomized and contents double-blinded. Symptoms, which assessed "blinded" observer, present 9% at all dosage levels, including lactose-free breakfast. Thus, under conditions study, modest lactose, equivalent 1 112 glasses milk, when taken with is well lactase-deficient Indian.