Lactase non-persistence and milk consumption in Estonia
作者： Margus Lember , Suvi Torniainen , Mart Kull , Riina Kallikorm , Peeter Saadla
关键词:
摘要: AIM: To define the frequency of C/T-13910 variant associated with lactase persistence/non-persistence trait and to analyze milk consumption non-persistent subjects in Estonia. METHODS: We genotyped 355 Estonians by polymerase chain reaction direct sequencing. Milk was analyzed a questionnaire, specially developed abdominal complaints. RESULTS: The genotype C/C-13910 (lactase non-persistence) found be 24.8% native Estonians. No other single nucleotide polymorphisms covering region 400 bp adjacent were found. Lactase non-persistence consume less than persistence subjects. CONCLUSION: defined confirms results previous studies based on indirect methods determining hypolactasia. is consistent previously reported figures adult-type hypolactasia Estonia. However, does not prevent intake many adults.
sci-hub.st 参考文章(21)
Albert D. Newcomer, Douglas B. McGill, Paul J. Thomas, Alan F. Hofmann, Tolerance to lactose among lactase-deficient American Indians Gastroenterology. ,vol. 74, pp. 44- 46 ,(1978) , 10.1016/0016-5085(78)90353-0
Mikko Kuokkanen, Ralf Butzow, Heli Rasinperä, Krzysztof Medrek, Mef Nilbert, Susanne Malander, Jan Lubinski, Irma Järvelä, Lactase persistence and ovarian carcinoma risk in Finland, Poland and Sweden International Journal of Cancer. ,vol. 117, pp. 90- 94 ,(2005) , 10.1002/IJC.21130
A. Tamm, Management of Lactose Intolerance Scandinavian Journal of Gastroenterology. ,vol. 202, pp. 55- 63 ,(1994) , 10.3109/00365529409091744
T. Sahi, Genetics and Epidemiology of Adult-type Hypolactasia Scandinavian Journal of Gastroenterology. ,vol. 202, pp. 7- 20 ,(1994) , 10.3109/00365529409091740
H. Arola, Diagnosis of Hypolactasia and Lactose Malabsorption Scandinavian Journal of Gastroenterology. ,vol. 202, pp. 26- 35 ,(1994) , 10.3109/00365529409091742
Sean Myles, Nourdine Bouzekri, Eden Haverfield, Mohamed Cherkaoui, Jean-Michel Dugoujon, Ryk Ward, Genetic evidence in support of a shared Eurasian-North African dairying origin Human Genetics. ,vol. 117, pp. 34- 42 ,(2005) , 10.1007/S00439-005-1266-3
Jesper T Troelsen, Jørgen Olsen, Jette Møller, Hans SjÖstrÖm, An upstream polymorphism associated with lactase persistence has increased enhancer activity. Gastroenterology. ,vol. 125, pp. 1686- 1694 ,(2003) , 10.1053/J.GASTRO.2003.09.031
Mikko Kuokkanen, Nabil S Enattah, Aino Oksanen, Erkki Savilahti, Arto Orpana, Irma Järvelä, Transcriptional regulation of the lactase-phlorizin hydrolase gene by polymorphisms associated with adult-type hypolactasia Gut. ,vol. 52, pp. 647- 652 ,(2003) , 10.1136/GUT.52.5.647
J. Jussila, K. Launiala, O. Gorbatow, Lactase deficiency and a lactose-free diet in patients with "unspecific abdominal complaints". Acta Medica Scandinavica. ,vol. 186, pp. 217- 222 ,(2009) , 10.1111/J.0954-6820.1969.TB01466.X
Sari R Anthoni, Heli A Rasinperä, Antti J Kotamies, Hanna A Komu, Harri K Pihlajamäki, Kaija-Leena Kolho, Irma E Järvelä, Molecularly defined adult-type hypolactasia among working age people with reference to milk consumption and gastrointestinal symptoms World Journal of Gastroenterology. ,vol. 13, pp. 1230- 1235 ,(2007) , 10.3748/WJG.V13.I8.1230