Effects of Estrogen on Activity and Fear-Related Behaviors in Mice

摘要: Estrogen has been shown to affect nonreproductive behaviors in humans and rodents, including anxiety, fear, activity levels. Rat studies have increases decreases these behaviors. Inconsistencies may be due differences testing conditions the extent which each test measures or activity. Few mouse performed. The present study was conducted address issues by examining effect of estradiol benzoate (EB) ovariectomized (OVX), C57BL/6 mice on a range behavioral paradigms measuring anxiety [open field (OF), dark-light transition (DLT), elevated plus maze (EP)], [running wheel (RW)], conditioned fear learning (FCon). In OF, vehicle (Veh) animals spent more time center than EB-treated were active overall. DLT, Veh both dark light compartments made transitions between two. EP, entered greater number arms. During FCon, EB froze stimulus. contrast, home cage RW, Veh. Factor analysis used characterize intertask correlations females' behavior explore possibility that estrogen an impact general arousal factor. sum, treatment heightened responses anxiety-provoking situations (OF, FCon), while increasing safer RW. We suggest result generally aroused animal.