The role of the estrogen receptor α in the medial amygdala and theventromedial nucleus of the hypothalamus in sexual motivation, socialrecognition, aggression and anxiety

摘要: 4 List of papers 5 INTRODUCTION 6 ERα and neurobiological basis sexual motivation 9 Concept test incentive From desire to Approach behaviors versus copulatory 10 Measuring testing 11 Criteria for a good preclinical model 12 central motive state 14 The role ovarian hormones ERs in the VMN MePDA 15 Background on 16 social recognition 18 Definition paradigms hormones, 19 medial amygdala 20 anxiety 21 estrogens 22 aggression 23 24 OBJECTIVES OF THE THESIS 25 GENARAL METHODS 27 Subjects shRNA technique knockdown Behavioral tests 28 SUMMARY PAPERS 30 PAPER I: II: 31 III: IV: 32 GENERAL DISCUSSION 34 CONCLUSIONS 42 LIST REFERENCES 43 60