Nephrotoxicity of borocaptate after short-term administration in rabbits.

摘要: Fifteen Chinchilla rabbits were treated by seven daily i.v. injections of two doses (25 or 50 mg/kg body wt.) sodium borocaptate (Na2B12H11SH), an agent now widely investigated for potential use in Boron Neutron Capture Therapy (BNCT) malignant brain tumors. Definite nephrotoxic lesions hyperemic and dilated glomeruli, degenerative necrobiosis with desquamation tubular epithelium, granular casts the distal convoluted collecting tubuli detected histopathological examination kidneys all animals without relation to dose borocaptate. The accumulation urea blood a reduction red cell counts were, however, statistically significant only receiving higher (50 In prevalent finding was dilation perivascular (Virchow-Robin's) spaces. growth retarded three died after injection 5th With respect these findings can no means be regarded as which is fully devoid activity towards healthy non-tumor tissue. Therefore, recent proposals enhance effectiveness BNCT repeated treatment should considered caution.